Published September 1988
| Version v1
Journal article
Synthesis of 14C- and 35S-labelled 2-mercaptobenzimidazoles
Description
14C- and 35S-labelled 2-mercaptobenzimidazole and 1-methyl-2-mercaptobenzimidazole were synthesized from 14C-carbon disulfide, 35S-thiourea, 14C-methyl iodide and 35S-thiourea, respectively, for use in studies on the mechanism of action of antithyroid drugs. The products were purified by chromatography on silica and isolated with radiochemical purities of greater than 98%, yields of 45-77% and specific activities of 2.1-5.3 mCi/mmole. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 25
- Journal Issue
- 9
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 985-990
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 20028826
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTITHYROID DRUGS; BENZIMIDAZOLES; CARBON 14; LABELLING; SULFUR 35; THIOUREAS
- Descriptors DEC
- AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBONIC ACID DERIVATIVES; DAYS LIVING RADIOISOTOPES; DRUGS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; ISOTOPES; LIGHT NUCLEI; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOISOTOPES; SULFUR ISOTOPES; YEARS LIVING RADIOISOTOPES