Synthesis, labelling and pharmacokinetic of two new fatty acid derivatives for cardiography

The introduction of a second phenyl ring into the aliphatic chain of ω-iodophenyl fatty acids should inhibit the dehydrogenases involved in the β-oxidation of fatty acids. Such modified radioactively labeled fatty acids should be expected to have longer retention times in the myocardium. 14-(p-iodophenyl)-12-p-phenylene tetradecanoic acid (PHIPA 12-2) and 16-(p-iodophenyl)-4-p-phenylene hexadecanoic acid (PHIPA 4-12) were synthesized and radioiodinated as model substances. Organ distribution studies in rats showed that both substances accumulated in the myocardium and that there was virtually no loss of activity at one and even at 4 hours. This suggests that β-oxidation is actually inhibited. (Author)