Published September 1990 | Version v1
Journal article Metadata-only

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated

Creators

  • 1. Johns Hopkins University School of Public Health, Department of Toxicology, Baltimore, MD (USA)

Description

Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated

Additional details

Publishing Information

Journal Title
Cell Regulation
Journal Volume
1
Journal Issue
10
Series
Cell Regul.
Journal Page Range
781-790
ISSN
1044-2030
CODEN
CELRE

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
22089847
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ATP-ASE; AUTORADIOGRAPHY; BRAIN; CALCIUM; CALCIUM 45; ENDOPLASMIC RETICULUM; IN VITRO; MESSENGER-RNA; OXALATES; PHOSPHOLIPIDS; RATS; RECEPTORS; RETENTION
Descriptors DEC
ACID ANHYDRASES; ALKALINE EARTH METALS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; CARBOXYLIC ACID SALTS; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; ELEMENTS; ENZYMES; ESTERS; EVEN-ODD NUCLEI; HYDROLASES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LIPIDS; MAMMALS; METALS; NERVOUS SYSTEM; NUCLEI; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANOIDS; ORGANS; PHOSPHOHYDROLASES; RADIOISOTOPES; RNA; RODENTS; VERTEBRATES