Distribution of 64Cu-Bleomycin in normal and tumor-bearing rats
Creators
- 1. Vienna Univ. (Austria). 1. Medizinische Klinik
- 2. Oesterreichische Studiengesellschaft fuer Atomenergie G.m.b.H., Seibersdorf. Inst. fuer Chemie
Description
Accumulation of a radioactive label in tumor tissue is required for scintigraphic visualization of the tumor and has been achieved by application of bleomycin as carrier. This chemotherapeutic polypeptide drug has been labeled with 64Cu. Thin layer chromatography of 64Cu-bleomycin which was incubated for 22 hours at 370C showed no changes of the chelate. When urine of the 64Cu-bleomycin treated animals was chromatographed considerable amounts (9.3%) of free 64Cu appeared 2 hours after injection of the chelate and dissociation was found to be almost complete 4 hours after injection of labeled bleomycin. The distribution of 64Cu-bleomycin is similar to that found with sup(99m)Tc-bleomycin with long lasting accumulation in kidneys and liver. Highest concentration ratios of the activity in mesenchymal tumor (Yoshida) and blood respectively were found 6 hours after intravenous administration of 64Cu-bleomycin. (author)
Availability note (English)
MF available from INIS under the Report Number.Files
8299072.pdf
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Additional details
Publishing Information
- Imprint Pagination
- 7 p.
- Report number
- SGAE--2564
INIS
- Country of Publication
- Austria
- Country of Input or Organization
- Austria
- INIS RN
- 8299072
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BLEOMYCIN; COPPER 64; NEOPLASMS; RADIONUCLIDE ADMINISTRATION; RADIONUCLIDE KINETICS; RATS; SCINTISCANNING; THIN-LAYER CHROMATOGRAPHY
- Descriptors DEC
- ANIMALS; ANTIBIOTICS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHROMATOGRAPHY; COPPER ISOTOPES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; KINETICS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; SEPARATION PROCESSES; VERTEBRATES
Optional Information
- Notes
- To be published inr En. J. Cancer.
- Secondary number(s)
- CH--181/76.