Published 1975 | Version v1
Journal article Metadata-only

Effect of γ irradiation on the activity of lecithin-cholesterol acyltransferase in plasma of the rat

Creators

  • 1. Institut National de la Sante et de la Recherche Medicale (INSERM), Hopital Purpan, 31 - Toulouse (France)

Description

Plasma cholesterol and lecithin-cholesterol-acyl-transferase activity are studied in irradiated rats. Ionizing radiations cause an increase of cholesterol levels in plasma, concerning mainly ester fraction. Lecithin-cholesterol-acyltransferase activity in plasma of irradiated rats is lowered 48 hours after exposure. This decreased rate of LCAT is probably the consequence of the post-irradiation hypercholesterolemia

Abstract (French)

On a etudie les variations du taux de cholesterol plasmatique et de l'activite de la lecithine-cholesterol-acyltransferase (LCAT) chez le rat irradie. L'irradiation entraine une elevation du taux de cholesterol plasmatique, concernant exclusivement le cholesterol esterifie. Parallelement, l'activite de la LCAT diminue dans le plasma 48 heures apres irradiation. Ce resultat pourrait etre lie a l'hypercholesterolemie consecutive a l'irradiation

Additional details

Additional titles

Original title (French)
Influence de l'irradiation sur l'activite de la lecithine-cholesterol acyltransferase plasmatique chez le rat

Publishing Information

Journal Title
C. R. Soc. Biol.
Journal Volume
169
Journal Issue
2
Series
C. R. Soc. Biol.
Journal Page Range
440-443

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
8281223
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BLOOD PLASMA; CHOLESTEROL; GAMMA RADIATION; METABOLISM; RATS; TRANSFERASES; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; ELECTROMAGNETIC RADIATION; ENZYMES; EXTERNAL IRRADIATION; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; STEROIDS; STEROLS; VERTEBRATES