Toxicity of inhaled 144CeCl3 in beagle dogs. X

Studies on the metabolism, dosimetry, and effects of inhaled 144CeCl3 in Beagle dogs are continuing to aid in assessing the biological consequences of inhaling 144Ce such as might be released in certain nuclear accidents. Studies on the organ distribution of inhaled 144CeCl3 have shown that the 144Ce deposited in lung is translocated at a moderately rapid rate to liver and skeleton and that significant radiation doses are accumulated by all three organs. Fifty-five dogs that inhaled 144CeCl3 and 15 control dogs are being observed for their life span. The 144Ce dogs have long-term retained burdens with values ranging from 20 to 2900 μCi. Pathological changes observed at autopsy are reported