Toxicity and biodistribution of nanoparticles

Within the project HISENTS, the sensor platform for nanotoxicity has been developed. Toxicity of nanoparticles is related to their concentration in the organ under consideration and time of exposure. Both, the concentration and exposure time, can be estimated from physiologically based pharmacokinetic (PBPK) modelling. The PBPK model enables to describe the ADME (absorption, distribution, metabolism, excretion) process and, hence, to predict the concentration of NPs in the organs and time of exposure. Application of the PBPK model is demonstrated on the treatment of in vivo distribution of PEGylated nanoparticles in rats. (authors)