Published January 2016 | Version v1
Journal article Metadata-only

68Ga-PSMA-11 PET/CT: a new technique with high potential for the radiotherapeutic management of prostate cancer patients

Creators

  • 1. Heidelberg Institute of Radiation Oncology, Heidelberg (Germany)
  • 2. German Cancer Research Center (DKFZ), Clinical Cooperation Unit Radiation Oncology, Heidelberg (Germany)
  • 3. University Hospital Heidelberg, Department of Radiation Oncology, Heidelberg (Germany)
  • 4. University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany)
  • 5. Technical University Munich, Department of Radiation Oncology, Munich (Germany)
  • 6. German Cancer Research Center (DKFZ), Department of Radiopharmaceutical Chemistry, Heidelberg (Germany)
  • 7. German Cancer Research Center (DKFZ), Clinical Cooperation Unit Nuclear Medicine, Heidelberg (Germany)

Description

Radiotherapy is the main therapeutic approach besides surgery of localized prostate cancer. It relies on risk stratification and exact staging. This report analyses the potential of [68Ga]Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning. A cohort of 57 patients with prostate cancer scanned with 68Ga-PSMA-11 PET/CT for radiotherapy planning was retrospectively reviewed; 15 patients were at initial diagnosis and 42 patients at time of biochemical recurrence. Staging results of conventional imaging, including bone scintigraphy, CT or MRI, were compared with 68Ga-PSMA ligand PET/CT results and the influence on radiotherapeutic management was quantified. 68Ga-PSMA ligand PET/CT had a dramatic impact on radiotherapy application in the presented cohort. In 50.8 % of the cases therapy was changed. The presented imaging technique of 68Ga-PSMA PET/CT could be a key technology for individualized radiotherapy management in prostate cancer. (orig.)

Availability note (English)

Available from: http://dx.doi.org/10.1007/s00259-015-3188-1

Additional details

Identifiers

DOI
10.1007/s00259-015-3188-1;

Publishing Information

Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
43
Journal Issue
1
Journal Page Range
p. 34-41
ISSN
1619-7070

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
47024469
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANTIGENS; BIOCHEMISTRY; CARCINOMAS; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; GALLIUM 68; LYMPH NODES; MEGA BQ RANGE 100-1000; METASTASES; NMR IMAGING; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RADIOPHARMACEUTICALS; RADIOTHERAPY; SCINTISCANNING; SKELETON; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; GALLIUM ISOTOPES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LYMPHATIC SYSTEM; MALE GENITALS; MATERIALS; MEDICINE; MEGA BQ RANGE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOACTIVITY RANGE; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY; THERAPY; TOMOGRAPHY