Blood cell labelling
Creators
- 1. Royal Marsden Hospital, Sutton (UK)
- 2. Institute of Cancer Research, Sutton, Surrey (UK). Physics Department
Description
The chief physical properties of the radionuclide In 111 are outlined, and compared with those of three other radionuclides, Tc99m, I131 and Cr51 which have similar applications. It is pointed out that the γ-rays of In111 are appreciably more penetrating in lead than those of Tc99m and the significance of this, both in the use of shielding on syringes and in the effectiveness of lead glass screens is discussed. Examples are given of the dosimetry for In111 labelled cells in humans and it is noted that the absorbed dose in the spleen per mCi (37 MBq) injected may be some 10 rad (0.1 Gy). The problems that have been noted of damage to cells arising from oxine labelling and now considered to be due to radiation damage are briefly reviewed. (Author)
Additional details
Additional titles
- Subtitle (English)
- Theory and methods: Radiation Hazards
Publishing Information
- Journal Title
- Wien. Klin. Wochenschr.
- Journal Volume
- 96
- Journal Issue
- 3
- Series
- Wien. Klin. Wochenschr.
- Journal Page Range
- 92-95
- ISSN
- 0043-5325
INIS
- Country of Publication
- Austria
- Country of Input or Organization
- Austria
- INIS RN
- 15030858
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ABSORPTION; BLOOD CELLS; CHROMIUM 51; COMPARATIVE EVALUATIONS; DOSIMETRY; GAMMA DECAY; HAZARDS; INDIUM 111; IODINE 131; LABELLING; LEAD; NUCLEAR MEDICINE; OXINE; RADIATION PROTECTION; RISK ANALYSIS; SHIELDING; SHIELDING MATERIALS; SPLEEN; SPLEEN CELLS; TECHNETIUM 99
- Descriptors DEC
- ANIMAL CELLS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CHROMIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DECAY; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; MEDICINE; METALS; MINUTES LIVING RADIOISOTOPES; NUCLEAR DECAY; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIDINES; QUINOLINES; RADIOISOTOPES; SOMATIC CELLS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES