Study of functional liver scintiscanning with sup(99m)technetium diethyl iminodiacetate in different hepatobiliary diseases

In 46 patients with five different affections, liver scintiscanning with sup(99m)technetium diethyl aminodiacetate was carried through. From the time/activity curves of different parts of the camera matrix picture the evaluation program of a camera process computer system calculated 25 function parameters, 8 of which were more closely described. The group with affections of the liver parenchyma showed a characteristic prolongation of the half-life period above the cardiac ragion of interest, a gentler curve rise and a retardation of Tsub(max) of the parenchyma curve as well as reduced evidence of activity of the intestine. For patients with extrahepatic cholostasis, prolonged and retarded accumulation of activity above the region of interest of the bibe duct, and reduced emission of activity from the intestine were characteristic, with the liver parenchyma parameters deviating only slightly from normal. In the groups with vascular stasis liver and nuclear findings the computation parameters did not permit to recognize a typical behaviour. The correlation of the serum bilirubin level with the half-life period above the cardiac region gave a correlation coefficient of r = 0.695. (orig./MG)