Published 2013
| Version v1
Book
Effect of ionizing radiation on immunogenicity of dendritic and tumor cells
- 1. Radiation Biology and Health Sciences Division, Bio-Medical Group, Bhabha Atomic Research Centre, Mumbai (India)
Description
Radiation therapy is an important treatment modality for cancer. But apart from direct cytotoxic effects on tumor cells, ionizing radiation (IR) can also mobilize tumor specific immunity. We have studied the efficacy of IR in inducing immunogenicity of dendritic cells and tumor cells. Irradiated (0.5-5 Gy) bone marrow (BM) cells were differentiated to dendritic cells in presence of GM-CSF and IL-4. Phenotypic and functional maturation of DC were assessed by expression of CD40, 80, 86 and MHC as well as MLR respectively. Expression of NKG2D ligands, MHC class I-related chain (MICA/MICB) on tumor cells was studied using specific antibodies and flow cytometry. NK cell killing was assessed by calcein release assay
Additional details
Publishing Information
- Publisher
- Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi
- Imprint Place
- Delhi (India)
- Imprint Title
- Proceedings of thirty second annual convention of Indian Association for Cancer Research: book of abstracts
- Imprint Pagination
- 336 p.
- Journal Page Range
- p. 167-168
Conference
- Title
- 32. annual convention of Indian Association for Cancer Research
- Acronym
- IACR 2013
- Dates
- 13-16 Feb 2013
- Place
- Delhi (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 45078723
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BONE MARROW CELLS; CARCINOMAS; CELL KILLING; RADIATION DOSES; RADIATION EFFECTS; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; NEOPLASMS; SOMATIC CELLS