Advances in trifluoromethylation or trifluoromethylthiolation with copper ${\text{CF}}_3$ or ${\text{SCF}}_3$ complexes

The copper ${\text{CF}}_3$ or ${\text{SCF}}_3$ complexes as the fluoride sources for the synthesis of trifluoromethylated or trifluoromethylthiolated compounds are reviewed. Compared with the ordinary fluoride reagents, the addition of reactant species in the reaction systems of copper trifluoromethyl or trifluoromethylthio complexes were less, so the reaction systems are relatively simple and easy to operate. In most cases, the trifluoromethylated or trifluoromethylthiolated products were obtained in moderate to excellent yields.

GRAPHICAL ABSTRACT

SYNOPSISThis mini-review highlights recent developments in trifluoromethylation or trifluoromethylthiolation using copper ${\text{CF}}_3$ or ${\text{SCF}}_3$ complexes, such as (phen)${\text{CuCF}}_3$, (phen)$\text{Cu}({\text{CF}}_3{)}_3$, (bpy)$\text{Cu}({\text{CF}}_3{)}_3$, $({\text{Ph}}_3\text{P}{)}_3{\text{CuCF}}_3$, and (bpy)${\text{CuSCF}}_3$. .