Comparative toxicity in rats vs hamsters of inhaled radon daughters with and without uranium ore dust
Description
Simultaneous exposures of rats and hamsters to inhaled radon daughters, with and without uranium ore dust, were performed daily for five months. Pulmonary pathology developing in 6 to 13 mo after cessation of daily exposures included interstitial fibrosis, emphysema, epithelial hyperplasia, squamous metaplasia, and malignant neoplasia. Rats showed a greater variety and more severe response to these uranium mine inhalation exposures than did hamsters. Inhalation of radon daughters with uranium ore dust displayed the site of greatest damage, including squamous carcinoma, from the nasopharynx to the lungs. Sixty percent of the rats exposed to radon daughters with ore dust developed primary pulmonary carcinomas, providing an appropriate short-term experimental animal model for investigation of respiratory tract carcinogenesis in uranium miners
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Additional details
Publishing Information
- Imprint Title
- Pacific Northwest Laboratory annual report for 1976 to the ERDA Assistant Administrator for Environment and Safety. Part 1. Biomedical Sciences
- Journal Page Range
- p. 56-60.
- Report number
- BNWL--2100(Pt.1)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 9360315
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- CARCINOGENESIS; DAUGHTER PRODUCTS; DUSTS; HAMSTERS; INHALATION; LUNGS; MINERS; NEOPLASMS; PATHOLOGY; RADON; RATS; RESPIRATORY SYSTEM DISEASES; TOXICITY; URANIUM MINES; URANIUM ORES
- Descriptors DEC
- ANIMALS; BODY; DISEASES; ELEMENTS; INTAKE; ISOTOPES; MAMMALS; MINES; NONMETALS; ORES; ORGANS; PATHOGENESIS; PERSONNEL; RARE GASES; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES