Elective nodal ultra hypofractionated radiation for prostate cancer: Safety and efficacy from four prospective clinical trials

Highlights: • Ultra-hypofractionated elective nodal RT was studied in 4 prospective trials. • The incidence of grade 3+ acute or late GI or GU toxicity was low. • Bowel and sexual quality of life worsened for 1 year post treatment. • Oncologic outcomes were very favorable, however longer follow-up is needed. • This is the largest prospective series of ultra-hypofractionated elective nodal RT. The role of elective nodal irradiation (ENI) in localized prostate cancer (PCa) is controversial. With increasing use of SBRT to the prostate, data is needed regarding the safety and efficacy of ENI using ultra-hypofractionated radiation (UHRT).