Published November 1990 | Version v1
Journal article Metadata-only

Increase in free calcium concentration in gamma-irradiated thymocytes may induce their death

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Obninsk (USSR). Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii

Description

Free Ca2+ concentration in thymocytes increased 0.5-1.5 h after gamma-irradiation (10 Gy) as was measured by Guin-2AM fluorescent probe. Cycloheximide, a protein synthesis inhibitor, suppressed Ca2+ increase and inhibited radiation-induced thymocyte death. EL-4 thymoma cells did not exhibit any changes in free Ca2+ concentration and interphase death after gamma-irradiation. It is believed that the radiation-induced increase of free Ca2+ concentration in thymocytes may induce their death

Additional details

Additional titles

Original title (Russian)
Повышение концентрации свободного кальция в тимоцитах при гамма-облучении может быт' индуктором их гибели

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
32
Journal Issue
6
Series
Radiobiologiya.
Journal Page Range
837-839
ISSN
0033-8192
CODEN
RADOA

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
23016772
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ASCITES TUMOR CELLS; BIOLOGICAL RADIATION EFFECTS; CALCIUM IONS; CELL KILLING; GAMMA RADIATION; RADIATION DOSES; THYMOCYTES
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; CHARGED PARTICLES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IONS; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; TUMOR CELLS