The influence of chemical compounds of different radioprotective efficiency on cyclic adenosine-3',5'-monophosphate and guanosine-3',5'-monophosphate in mouse blood plasma

A study was made of seven radioprotective agents of different chemical classes (sulfur-containing, indolylalkylamines, and imidazol, urea and pyridasine derivatives) and also of their six structural analogs without radioprotective properties on the content of cyclic nucleotides in blood plasma and on the postirradiation survival of mice. There was a correlation between the ability of the preparations to increase the level of cyclic adenosine-3', 5'-monophosphate and their radioprotective properties; with guanosine-3', 5'-monophosphate, this correlation was absent