correlation between the degree of malignancy of pheochromocytoma and the maximum standardized uptake value measured by 18F-FDG PET/CT
Creators
- 1. Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University (China)
Description
Objective: To analyze the correlation of 18F-FDG SUVmax with plasma free metanephrines (MN), normetanephrine (NMN) and 131I-meta-iodobenzylguanidine (MIBG) scintigraphy,and to explore the role of 18F-FDG PET/CT in distinguishing between benign pheochromocytoma (BPCC) and malignant pheochromocytoma (MPCC). Methods: 18F-FDG PET/CT, plasma MN and NMN, and 131I-MIBG SPECT were studied in 19 patients with pheochromocytoma confirmed by postoperative pathology, including 11 benign and 8 malignant cases. ROC curve was drawn, and 18F-FDG SUVmax of patients with MN (NMN) positive and negative results was compared using two independent sample t-test by SPSS 17.0. Results: Both BPCC and MPCC showed positive findings on 18F-FDG PET/CT.SUVmax of MPCC (19.40 ± 7.39) was significantly higher than that of BPCC (7.44 ± 4.47; t=-4.40, P<0.01). Using a cut-off value of 8.85 on the ROC curve for determining BPCC and MPCC, the sensitivity, specificity and accuracy was 8/8, 81.8% (9/11) and 89.5% (17/19), respectively. SUVmax of adrenal lesions (19.75 ± 8.64) was significantly higher than that of extra-adrenal lesions (9.12 ± 5.83; t=- 3.18, P<0.05). The difference of SUVmax between new and recurrent lesions was not significant (t=-1.68, P>0.05). SUVmaxof MN negative cases (13.57 ±8.61) was significantly higher than that of MN positive cases (6.63 ±2.42; t=2.70, P<0.05). The difference of SUVmax between NMN negative and positive cases was not significant (t=-0.93, P>0.05). Seven patients underwent 131I-MIBG SPECT, among which one case with BPCC and four cases with MPCC were negative. The 18F-FDG PET/CT results were positive in all seven patients. Conclusions: 18F-FDG PET/CT can be used as a second-line diagnostic tool for patients with negative MN or indeterminate 131I-MIBG SPECT findings. The degree of FDG uptake has potential in the differentiation of benign from malignant pheochromocytoma. (authors)
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Nuclear Medicine and Molecular Imaging
- Journal Volume
- 32
- Journal Issue
- 4
- Journal Page Range
- p. 259-264
- ISSN
- 2095-2848
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 46111507
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ACCURACY; CAT SCANNING; COMPARATIVE EVALUATIONS; CORRELATIONS; DIAGNOSIS; FLUORINE 18; FLUORODEOXYGLUCOSE; IODINE 131; MIBG; NEOPLASMS; PATHOLOGY; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SCINTISCANNING; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPECIFICITY; UPTAKE
- Descriptors DEC
- ANTIMETABOLITES; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBONIC ACID DERIVATIVES; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; FLUORINE ISOTOPES; GUANIDINES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TOMOGRAPHY
Optional Information
- Notes
- 3 figs., 26 refs.