Dosimetric Studies in Normal Mice of 177Lu-DOTA-SP and 177Lu-DOTA-His2-MG
Creators
- 1. Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)
- 2. Comision Nacional de Energia Atomica (Argentina)
Description
DOTA-Substance-P (SP) and DOTA-minigastrin (His2-MG) labeled with 177Lu could be used in peptide receptor radionuclide therapy (PRRT) for treatment of various tumour species. Biodistribution studies of both radiopharmaceuticals in normal mice were performed at different times. Absorbed doses in mouse organs were estimated and extrapolated to humans. Dosimetric calculations showed that kidneys received the highest dose, for both radiopharmaceuticals. The Maximum Tolerated Activity (MTA) of 177Lu-DOTA-SP that can be administered without kidney toxicity are 414 and 422 MBq/kg for the standard adult man and woman, respectively. In the same way, the MTA of 177Lu-DOTA-His2-MG are 488 and 518 MBq/kg for the standard adult man and woman, respectively. (authors)
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44096788.pdf
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Additional details
Additional titles
- Original title (Spanish)
- Estudios dosimétricos en los ratones normales de
Identifiers
Publishing Information
- Publisher
- ARN
- Imprint Place
- Buenos Aires (Argentina)
- Imprint Title
- Technical Memory 2010. Nuclear Regulatory Authority
- Imprint Pagination
- 228 p.
- Journal Page Range
- p. 141-145
- Report number
- INIS-AR-A--14
Conference
- Title
- International Symposium on Technetium and other Radiometals in Chemistry and Medicine
- Dates
- 8-11 Sep 2010
- Place
- Bressanone, Bolzano (Italy)
INIS
- Country of Publication
- Argentina
- Country of Input or Organization
- Argentina
- INIS RN
- 44096788
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ABSORBED RADIATION DOSES; ADULTS; KIDNEYS; LUTETIUM 177; MICE; NUCLEAR MEDICINE; RADIOPHARMACEUTICALS
- Descriptors DEC
- AGE GROUPS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DOSES; DRUGS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUTETIUM ISOTOPES; MAMMALS; MATERIALS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIATION DOSES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI; RODENTS; VERTEBRATES
Optional Information
- Notes
- 2 refs., 1 figs., 2 tabs. Poster Imprint:Memoria Tecnica 2010. Autoridad Regulatoria Nuclear