The relationship between the degree of liver fibrosis and serum markers in patient with hepatic diseases

To study the relationship between the degree of liver fibrosis and serum markers in patients with hepatic diseases, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (GGT), total bilirubin (TBIL), albumin (ALB), globulin (GLO), platelet (PLT), prothrombin time (PT), procollagen type III (PIIINP), hyaluronic acid (HA), laminin (LN) and collagen type IV in 114 patients with different causes hepatic disease were determined. The liver puncture biopsy was also carried out to determine the stages of liver fibrosis. The results showed that the serum albumin, globulin, platelet, prothrombin time, PIIINP, HA, collagen type IV had significant difference in different stages of liver fibrosis. The serum platelets and albumin levels were negatively correlated with the degree of liver fibrosis. The serum PT and GLO levels were positively correlated with time course of liver fibrosis. The serum PIIINP, HA and collagen type IV levels were positively correlated with degree of liver fibrosis. The serum albumin, globulin, prothrombin time, platelets, PIIINP, HA, collagen type IV were correlated with the progress of the liver fibrosis. The prothrombin time and platelets have directive significance in the diagnosis of liver cirrhosis and also used to judge the stage of liver fibrosis in some extent. The serum PIIINP, HA and collagen type IV levels may better reflect the process of liver fibrosis. (authors)