Published August 1997
| Version v1
Journal article
The effects of 6 Gy whole body irradiation on wound macrophage function
Creators
- 1. Third Military Medical Univ., Chongqing, SC (China). Inst. of Combined Injury of PLA
Description
Macrophages play and important role in wound healing. The effects of 6 Gy whole body irradiation on wound macrophage function was studied by a rat dorsum incision in which polyvinyl alcohol sponges were implanted. It was found that the phagocytic activity, the release of tumor necrosis factor and interleukin-1, the regulatory effect on wound fibroblast proliferation by wound macrophages, as well as the number of macrophages in wound, were significantly decreased on day 3,5,8 after wounding. The results indicated that the important mechanism of depression of wound healing after whole body irradiation is the decrease in number and impairment of function of wound macrophages in the early stage of wound healing
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 15
- Journal Issue
- 3
- Journal Page Range
- p. 175-178.
- ISSN
- 1000-3436
- CODEN
- FYYXEA
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29001434
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL FUNCTIONS; BIOLOGICAL RADIATION EFFECTS; FIBROBLASTS; GAMMA RADIATION; MACROPHAGES; RATS; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; PHAGOCYTES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES