Radiation damage in mouse embryos exposed to 1 rad X-rays or negative pions
Description
Pregnant mice of two different strains (F/A and NMRI) were exposed to 1 rad of whole-body pion- or X-irradiation at day 8 of gestation. Lucanthone (Miracil D), a known radiosensitizer in various biological systems, was applicated 30 min before irradiation. Five days after treatment the fetuses were observed for development anomalies. In both strains of mice it was found that the radiation dose as low as 1 rad results in a significant increase in the rate of abnormal fetuses compared to nonirradiated, but restrained fetuses. Comparing the effectiveness of negative pions (peak irradiation) with X-rays for teratogenic effects, the RBE was between 1.7 and 1.9. The application of Lucanthone increased the number of damaged fetuses and led to various degrees of sensitization depending on the mouse strain and dosage used. Differences between the strains as regards the frequency of damages are explained by different developmental stages at the time of treatment. (orig.)
Abstract (German)
Mausweibchen (Fuellinsdorf Albino und NMRI Stamm) wurden am Tag 8 der Gestation mit 1 rad Ganzkoerper bestrahlt. Lucanthon (Miracil D), ein wirksamer Strahlensibilisator, wurde 30 Min. vor Bestrahlung i.p. appliziert. Fuenf Tage nach der Bestrahlung erfolgte die Untersuchung der Feten auf Entwicklungsstoerungen hin. Im Vergleich zu unbestrahlten Feten fuehrte eine Bestrahlung mit 1 rad in beiden Mausstaemmen zu einer signifikanten Erhoehung der Anomalierate. Die Wirksamkeit von negativen Pionen (Peak-Bestrahlung) scheint gegenueber Roentgenstrahlen erhoeht zu sein, der RBW-Wert variiert zwischen 1,7 und 1,9. Die Applikation von Lucanthon erhoehte die Anzahl geschaedigter Feten und zeigte, je nach Mausstamm und Dosierung, unterschiedliche Sensibilisierung. Unterschiedliche Schaedigungsfrequenzen bei den beiden Mausstaemmen werden durch verschiedene Entwicklungsstadien zur Zeit der Behandlung erklaert. (orig.)Additional details
Identifiers
Publishing Information
- Journal Title
- RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
- Journal Volume
- 127
- Journal Issue
- 09
- Series
- Fortschr. Geb. Roentgenstr. Nuklearmed.
- Journal Page Range
- 276-280
- ISSN
- 1438-9029
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 9357582
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CONGENITAL MALFORMATIONS; DOSE-RESPONSE RELATIONSHIPS; EFFICIENCY; EMBRYOS; FEMALES; FETUSES; MICE; PIONS MINUS; PRENATAL IRRADIATION; RADIATION INJURIES; RADIOSENSITIZERS; RBE; WHOLE-BODY IRRADIATION; X RADIATION
- Descriptors DEC
- ANIMALS; ANTIMATTER; ANTIMESONS; ANTIPARTICLES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BOSONS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; EXTERNAL IRRADIATION; HADRONS; INJURIES; IONIZING RADIATIONS; IRRADIATION; MALFORMATIONS; MAMMALS; MATTER; MESONS; PATHOLOGICAL CHANGES; PIONS; PSEUDOSCALAR ANTIMESONS; PSEUDOSCALAR MESONS; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES
Optional Information
- Notes
- 2 figs.; with refs.; Updated automatically by Metadata and Full-Text Enrichment Agent