Published 1989
| Version v1
Book
Quantitative analysis of receptor binding studies
Creators
- 1. Uppsala University (Sweden). Svedberg Laboratory
- 2. Uppsala Univ. (Sweden). Dept. of Radiation Sciences
- 3. Uppsala University (Sweden). Svedberg University, Department of Neurology
Description
It is analyzed during which conditions the technique of a reference tissue can be applied in receptor binding studies with PET, which assumptions have to be made and how the qualification will be affected. A compartment model which includes unspecific binding is used. The reference and target tissues are allowed to have different distribution characteristics. Volume effects are included. The model is simulated with different specific activities in order to observe the effects of the bound ligand concentration. Different techniques to calculte the receptor density Bmax and ligand rates are suggested. (author). 7 refs.; 8 figs.; 1 tab
Additional details
Publishing Information
- Publisher
- Kluwer.
- Imprint Place
- Dordrecht (Netherlands)
- ISBN
- 0-7923-0254-0
- Imprint Title
- Positron Emission Tomography in clinical research and clinical diagnosis: tracer modelling and radioreceptors
- Imprint Pagination
- 301 p.
- Journal Volume
- 15
- Series
- Developments in Nuclear Medicine.
- Journal Page Range
- p. 65-80.
Conference
- Title
- Workshop on positron emission tomography.
- Dates
- 20-22 Oct 1988.
- Place
- Brussels (Belgium).
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 21010657
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BRAIN; COMPARTMENTS; DISTRIBUTION; DOPAMINE; LABELLED COMPOUNDS; LIGANDS; MATHEMATICAL MODELS; POSITRON COMPUTED TOMOGRAPHY; RADIONUCLIDE KINETICS; RECEPTORS; SIMULATION
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; HYDROXY COMPOUNDS; KINETICS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; STEROIDS; SYMPATHOMIMETICS; TOMOGRAPHY