Synthesis of organic compounds with disulfide bridge labelled with 35 S

This work had as purpose: a) synthesis of aliphatic compounds with disulfide bridge, and also the synthesis of aromatic compounds with disulfide bridge, substituted with various functional groups; b) labelling with 35 S of certain positions of the obtained organic compounds having disulfide bridge in their molecular structures. At the same time, we studied the 35 S-labelling techniques of these compounds. The organic syntheses used in the process of labelling of organic compounds containing disulfide bridge, have the advantage to obtain a structure with a definite position of radioactive labelling (of 35 S). The 35 S radioisotope is an important element due to its applications in the field of organic compounds labelling. Among its characteristics we mention: the half time is 87 days, the maximum energy of beta radiation is 0.167 MeV and it constitutes a pure beta transmitter. The activity measurements were carried out with a 3385 Tricarb-Packard spectrometer, based on liquid scintillators. Thanks to its properties 35 S has several applications in organic chemistry and biology. (authors)