Liposomal delivery of benzoporphyrin derivative (BPD) to tumors
- 1. British Columbia University, Vancouver (Canada). Department of Microbiology
- 2. Quadra Logic Technologies Inc., Vancouver (Canada)
Description
A liposomal formulation of benzoporphyrin derivative, monoacid ring A (BPD), a potent lipophilic photosensitizer, was evaluated in a mouse tumor model. DBA/2 mice, bearing the M1 (rhabdomyosarcoma) tumor were injected intravenously with 14C-BPD (at 4 mg/kg) formulated in either liposomal suspension (L-14C-BPD) or 6% DMSO-PBS solution (A-14C-BPD) and the tumor accumulation of 14C-BPD and biodistribution in mouse tissues were determined and compared. Efficiency of photodynamic treatment was determined in the M1 tumor model in DBA/2 mice following intravenous injection of BPD in either formulation (0.5-3 mg/kg) 3 h prior to laser light (690 nm) treatment (150 or 210 J/cm2). Distribution of L and A-14C-BPD in human blood and plasma was determined in vitro. (author). 11 refs., 5 figs., 2 tabs
Additional details
Publishing Information
- Publisher
- Excerpta Medica.
- Imprint Place
- Amsterdam (Netherlands)
- ISBN
- 0 444 81430 2
- Imprint Title
- Photodynamic therapy and biomedical lasers
- Imprint Pagination
- 1037 p.
- Journal Volume
- 1011
- Series
- International Congress Series.
- Journal Page Range
- p. 549-551.
Conference
- Title
- International Symposium on Photodynamic Therapy and Medical Laser Applications.
- Dates
- 24-27 Jun 1992.
- Place
- Milan (Italy).
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 24056838
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CARBON 14; CARBON 14 COMPOUNDS; LASER RADIATION; LIPOSOMES; MICE; PHOTOSENSITIVITY; PORPHYRINS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RHABDOMYOSARCOMAS; THERAPY; TISSUE DISTRIBUTION; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON COMPOUNDS; CARBON ISOTOPES; CARBOXYLIC ACIDS; DISEASES; DISTRIBUTION; DRUGS; ELECTROMAGNETIC RADIATION; EVEN-EVEN NUCLEI; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MEDICINE; MYOSARCOMAS; NEOPLASMS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATIONS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SARCOMAS; SENSITIVITY; VERTEBRATES; YEARS LIVING RADIOISOTOPES