Synthesis of radioiodo-[4-(2-iodo-4-fluoro-benzoyl)piperidin-1-yl]-2'-acetonaphthone

Radioiodo-[4-(2-I-4-fluorobenzoyl)piperidin-1-yl]-2'-acetonaphthone was synthesised as a potential in vivo tracer of the glutamate release inhibiting system. The labeling was performed by Cu1+ assisted non isotopic nucleophilic exchange on [4-(2-bromo-4-fluorobenzoyl)piperidin-1-yl]-2'-acetonaphtone. The labeled compound is obtained after HPLC separation and mini-column recovery. The brominated substrate is obtained by KI catalysed coupling of 2-bromo-acetonaphthone to the piperidinyl entity in ethanol at room temperature using triethylamine. (author)