Published 1988 | Version v1
Book Metadata-only

Cellular oncogenes encoding nuclear proteins

Creators

  • 1. European Molecular Biology Lab., Heidelberg (Germany, F.R.)
  • 2. Zentrum fur Molekulare Biologie der Universtat Heidelberg, Heidelberg (Germany, F.R.)
  • 3. Max Planck Institut fur Molekulare Genetik, Berlin (Germany, F.R.)

Description

The fos oncogene has been detected in two different mouse osteosarcoma viruses, in the Finkel-Biskis-Jenkins mouse osteosarcoma virus (FBJ-MSV), isolated from a spontaneous osteosarcoma-like tumor in CF-1 mouse, and in the Finkel-Biskis-Reilly mouse osteosarcoma virus (FBR-MSV), and recovered from a radiation 90Sr-induced osteosarcoma in a X/Gf mouse. Both retroviruses induce chondro-osseous neoplasma and fibrosarcomas upon inoculation into newborn rodents. In the past years, the function of the viral fos genes and their cellular progenitor, the c-fos proto-oncogene, have been the subject of intense research efforts. This paper describes how the function of the c-fos proto-oncogene product in biological processes has been addressed by two approaches

Additional details

Additional titles

Subtitle (English)
fos, myb, myc, and erbA

Publishing Information

Publisher
Marcel Dekker Inc.
Imprint Place
New York, NY (USA)
Imprint Title
Cellular oncogene activation
Imprint Pagination
392 p.
Journal Page Range
p. 1-54.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
22008445
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
GENETIC MAPPING; MICE; MOLECULAR BIOLOGY; ONCOGENES; ONCOGENIC VIRUSES; RADIATION EFFECTS; RESEARCH PROGRAMS; SARCOMAS; SOMATIC CELLS
Descriptors DEC
ANIMAL CELLS; ANIMALS; DISEASES; GENES; MAMMALS; MICROORGANISMS; NEOPLASMS; PARASITES; RODENTS; VERTEBRATES; VIRUSES