Published September 1982
| Version v1
Journal article
Synthesis of [3H]- and -[14C]-labeled sulprostone
- 1. Central Research, Pfizer Inc., Groton, Connecticut
Description
The synthesis of N-methanesulfonyl 16-phenoxy-omega-tetranor PGE2 carboxamide (sulprostone--CP-34,089/ZK-57,671) labeled with tritium and carbon-14 is described. Sulprostone labeled with tritium in the phenoxy moiety by means of catalytic hydrogenolysis was obtained in a 17% radiochemical yield with a specific activity of 1.0 Ci/mmol. The methanesulfonamide-14C derivative of sulprostone was prepared from methyl-14C iodide in an 11.8% radiochemical yield having a specific activity of 18.8 mCi/mmol
Additional details
Publishing Information
- Journal Title
- Prostaglandins
- Journal Volume
- 24
- Journal Issue
- 3
- Series
- Prostaglandins.
- Journal Page Range
- 331-339
- ISSN
- 0090-6980
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14787725
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; DIAGNOSIS; LABELLING; PROSTAGLANDINS; RADIOPHARMACEUTICALS; TRITIUM COMPOUNDS
- Descriptors DEC
- CARBON COMPOUNDS; DRUGS; HYDROGEN COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; RADIOACTIVE MATERIALS; SYNTHESIS