Clinical significance of measurement of changes of serum IL-2, SIL-2R levels after chemotherapy in patients with lung carcinoma
Creators
- 1. Zhenjiang First People's Hospital, Zhenjiang, Jiangsu (China). Dept. of Nuclear Medicine
Description
Objective: To study the changes of serum IL-2 and SIL-2R levels after chemotherapy in 36 patients with lung carcinoma. Methods: Serum IL-2 (with RIA) and SIL-2R (with ELISA) levels were measured in 36 patients with lung carcinoma both before and after chemotherapy as well as in 35 controls. Results: Before chemotherapy, in the patients the serum IL-2 levels were significantly lower and serum SIL-2R levels were significantly higher than those in the controls (P<0.01). Six months after chemotherapy, those patients without recurrence (n=20) had their IL-2 and SIL-2R levels returned to normal but in those with recurrences (n=12) the levels were about the same as before. Conclusion: Cytokines IL-2 and SIL-2R levels changes could reflect the immunostatus of the patient as well as the progress of disease and could be of prognostic value. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 17
- Journal Issue
- 4
- Journal Page Range
- p. 255-256
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36114251
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD SERUM; CARCINOMAS; CHEMOTHERAPY; DIAGNOSIS; EVALUATION; IMMUNITY; LUNGS; LYMPHOKINES; RADIOIMMUNOASSAY; RECEPTORS
- Descriptors DEC
- BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DISEASES; GROWTH FACTORS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MEDICINE; MEMBRANE PROTEINS; MITOGENS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RESPIRATORY SYSTEM; THERAPY; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 8 refs.