Labeling and Biodistribution of 99mTc-4-Hydroxy-7-fluoro Quinoline-3 Carboxylic acid Complex

Prompt localization of infection sites is essential for initiating appropriate therapeutic measures. There have been major advances in the management of patients suffering from infective and/or inflammatory disorders as result of introduction of new drugs with high sensitivity and specificity. The aim of this study is to develop simple and easy formulation of 4-Hydroxy-7-fluoro quinoline-3 carboxylic acid with 99mTc, ready to use labeling kit for infection imaging. The optimization of the labeling yield of 4-Hydroxy-7-fluoro quinoline-3-carboxylic acid (4) with 99m Tc was described. At ph 3, 99m Tc-(4) was obtained with a high radiochemical yield of 95.2% by adding 99m Tc to 10 mg of compound (4) in the presence of 100 μ SnCI2 at 100 degree C. In vivo 99mTc(4) pharmacokinetic studies were carried in experimentally induced infection, in the left thigh, using Staphylococcus aureus in rats. Both thighs of thc rats were dissected and counted and the ratio of bacterial infected thigh/contralateral thigh was then evaluated. 99mTc(4) showed higher uptake (T/NT = 4.5± 0.5) in the infectious lesion tissue than normal tissue. So, 99mTc(4) complex is simple and stable preparation for infection imaging sites