Published February 2019 | Version v1
Journal article Metadata-only

p53 Loss Mitigates Early Volume Deficits in the Brains of Irradiated Young Mice

Creators

  • 1. Department of Medical Biophysics, University of Toronto, Toronto, Ontario (Canada)
  • 2. Translational Medicine, Hospital for Sick Children, Toronto, Ontario (Canada)
  • 3. Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario (Canada)
  • 4. Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, Toronto, Ontario (Canada)
  • 5. Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada)
  • 6. Ontario Institute for Cancer Research, Toronto, Ontario (Canada)

Description

Pediatric cranial radiation therapy results in lasting changes in brain structure. Though different facets of radiation response have been characterized, the relative contributions of each to altered development is unclear. We sought to determine the role of radiation-induced programmed cell death, as mediated by the Trp53 (p53) gene, on neuroanatomic development.

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2018.09.014;
PII
S0360301618337611;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
103
Journal Issue
2
Journal Page Range
p. 511-520
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55057280
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
APOPTOSIS; BRAIN; GENES; IRRADIATION; MICE; PEDIATRICS; RADIOTHERAPY
Descriptors DEC
ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; MAMMALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2018 The Authors. Published by Elsevier Inc.