Radiation response of melanocytes
Description
Radiation response of melanocytes in resting and growing hair follicles is being studied using black C57B1/6J mice. The mid-dorsum of the posterior one-third of the body was exposed to 60Co gamma-rays, shielding the remainder of the body. Hair from the second growth cycle after irradiation was plucked and scored individually for the greying effect. The percentage of black hairs in a sample reflects the fraction of melanocytes surviving. Single and fractionated dose survival curves are being determined over a dose range of 300-1200 rad. The results are not affected by hair loss. The radiosensitivity of melanocytes in resting and growing phase follicles is being determined. Fractionated regimens using time intervals from 45 minutes to 12 hours are also being given to study the repair kinetics of melanocytes
Additional details
Publishing Information
- Publisher
- Radiation Research Society.
- Imprint Place
- Philadelphia, PA (USA)
- Imprint Title
- Abstracts of papers for the thirty-second annual meeting of the Radiation Research Society
- Journal Page Range
- p. 109.
Conference
- Title
- 32. annual scientific meeting of Radiation Research Society.
- Dates
- 1 Mar 1984.
- Place
- Orlando, FL (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18050788
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CELL CONSTITUENTS; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; HAIR; HAIR FOLLICLES; MELANIN; MICE; RADIOSENSITIVITY; SKIN
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; ELECTROMAGNETIC RADIATION; HYDROXY COMPOUNDS; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PIGMENTS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES