Solubility and transfer solvation thermodynamics of l-isoleucine and l-serine in water to aqueous solution of Na2SO4 and K2SO4 from 288.15 K to 303.15 K

Highlights: • Solubility of l-isoleucine and l-serine at aqueous electrolytes solutions was measured from 288.15 to 308.15 K. • The standard transfer Gibbs free energies, enthalpy, entropy of l-isoleucine and l-serine were measured. • The chemical transfer free energies and entropies of l-isoleucine and l-serine were computed. • The stability of l-isoleucine and l-serine in aquo-electrolytes was explained. The solubilities of l-isoleucine and l-serine in aqueous sodium sulfate (Na₂SO₄) and potassium sulfate (K₂SO₄) from 298.15 to 308.15 K are presented. The solubilities are measured by 'gravimetric' method. The relative solubility of the amino acids is calculated to explain the salting-in and salting-out effect in the electrolytes solutions. The amino acids solvation thermodynamical parameters are computed. The chemical effects of the transfer Gibbs energies for both the amino acids are estimated by subtracting the cavity effect and dipole-dipole interaction effect from the total transfer energies. The chemical transfer energetics is employed to discuss solute-solvent and solvent-solvent interactions.