Published April 1992 | Version v1
Journal article Metadata-only

Severe complications of 5-fluorouracil and cisplatin with concomitant radiotherapy in inoperable non-metastatic squamous cell oesophageal cancer after intubation - early termination of a prospective randomised trial

Creators

  • 1. Pretoria Univ. (South Africa). Dept. of Radiotherapy
  • 2. Pretoria Univ. (South Africa). Dept. of Medical Oncology
  • 3. Pretoria Univ. (South Africa). Dept. of Surgery

Description

This brief letter describes a randomized trial in which radiotherapy is added to concomitant 5- fluorouracil and cisplatin therapy in patients with inoperable non-mestastatic squamous cell oesophageal cancer after palliative intubation. An interim analysis showed that patients randomized to observation had a median survival of 19 weeks while patients treated with radiotherapy, 5- fluorouracil and cisplatin had a median survival of 11 weeks. This difference in survival was due to the toxicity of the combined chemoradiotherapy and tube which resulted in early termination of the trial. (UK)

Additional details

Publishing Information

Journal Title
European Journal of Cancer (1990)
Journal Volume
28A
Journal Issue
4-5
Journal Page Range
p. 1005-1006.
ISSN
0959-8049
CODEN
EJCAEL

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24015244
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CHEMOTHERAPY; COMPARATIVE EVALUATIONS; ESOPHAGUS; FLUOROURACILS; NEOPLASMS; PATIENTS; RADIOTHERAPY; TOXICITY; TUBES
Descriptors DEC
ANIMALS; ANTIMETABOLITES; AZINES; BODY; DIGESTIVE SYSTEM; DISEASES; DRUGS; EVALUATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MAMMALS; MAN; MEDICINE; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; PYRIMIDINES; THERAPY; URACILS; VERTEBRATES