Lung uptake of sup(99m)Tc-sulfur colloid secondary to androgen therapy in patients with anaemia

Diffuse lung uptake of sup(99m)Tc-sulphur colloid was observed in 13 chronically anaemic patients on virilizing androgen therapy who were undergoing bone marrow imaging. This contrasts with the normal distribution of the sulphur colloid in the bone marrow with no activity noted within the lungs of 14 patients not on androgen therapy. It is postulated that the dose of androgen itself or the oestrogen degradation products of the androgens stimulate the reticuloendothelial system resulting in diffuse lung uptake of radiocolloid. (U.K.)