Significance of cartridges and resins used in a purification column during ¹⁸F-fluorodeoxyglucose synthesis

The aims and objective of this study to share the 15 years of working experience regarding importance of cartridges and resins used in a Purification Column during ¹⁸F-FDG synthesis. ¹⁸F- fluorodeoxyglucose (¹⁸F-FDG) is common radiotracer used in positron emission tomography (PET). ¹⁸F-FDG is synthesized in a PET radiochemistry synthesis module and purification column is an integral part of ¹⁸F-FDG synthesis. The purification column has four integral parts, namely of ion exchange retardation resin, cation exchange resin, C18 bonded silica, Neutral Alumina. The purification column plays a very important role during the synthesis of ¹⁸F-FDG. If all parts of the purification column are intact, then maximum transfer of produced ¹⁸F-FDG from reaction vessels to the final product vial takes place. The total yield of ¹⁸F-FDG is also dependent upon the purification column. If all components of purification column placed tightly and properly charged then there is a high possibility of maximum yield of final product without impurities. (author)