A method for labelling bleomycin and mannitol using a solid reductant

Bleomycin and mannitol seem to localize particularly in animal neoplastic tissue. Analyzing the structure of the two molecules, the presence of sites combining /sup 99m/Tc can be hypothesized, particularly for bleomycin. Many methods for labelling bleomycin with /sup 99m/Tc have been reported, but these radiopharmaceuticals have not often been used clinically. The aims of this study were: (1) to compare a method based on the utilization of a solid reductant (SnO) with a more often used method involving the utilization of Sn Cl/sub 2/ as a reductant; (2) to propose two reliable labelling methods which prove easy to perform in any laboratory