Published July 2006
| Version v1
Journal article
Synthesis and evaluation of fluorine-18 labelled compounds for imaging of bacterial infections with pet
- 1. Institut fuer Molekulare Biophysik, Radiopharmazie und Nuklearmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitaetsklinik der Ruhr-Universitaet, Bochum, Georgstrasse 11, 32545 Bad Oeynhausen (Germany)
- 2. Institut fuer Laboratoriums-und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitaetsklinik der Ruhr-Universitaet, Bochum, Georgstrasse 11, 32545 Bad Oeynhausen (Germany)
Description
Syntheses of no carrier added (n.c.a.) 6-fluoro-1,4-dihydro-1-cyclopropyl-4-oxo-7-[4-[18F]fluoro-phenacyl -1-piperacinyl]-chinolincarboxylic acid ([18F]COPCA) and n.c.a. 4-[18F]fluoro-benzoyl-ubiquicidin 29-41 ([18F]UBI 29-41) are described. [18F]COPCA was synthesised within 120 min with a radiochemical yield of 9-12%. [18F]UBI 29-41 was synthesised within 150 min with a radiochemical yield of 15-20%. Both compounds had a specific activity of more than 35 GBq/μ mol. The biological activity was verified by measuring its binding to Staphylococcus aureus bacteria. Specific binding was found for [18F]UBI 29-41 (12-17%), whereas no specific binding for [18F]COPCA was found
Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2006.02.095;
- PII
- S0969-8043(06)00132-1;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 64
- Journal Issue
- 7
- Journal Page Range
- p. 802-807
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 38025385
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- FLUORINE 18; LABELLED COMPOUNDS; LABELLING; STAPHYLOCOCCUS; SYNTHESIS
- Descriptors DEC
- BACTERIA; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MICROORGANISMS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.