Effect of time period after boric acid injection on 10B absorption in different regions of adult male rat's brain
- 1. Nuclear Engineering Department, Science and Research Branch, Islamic Azad University, Poonak Sq. PO Box 14515-775, Tehran (Iran, Islamic Republic of)
- 2. Laboratory of Basic Science and Neuroscience, Basic Science Dept, Faculty of Allied Medicine, Cellular and Molecular Research Center, Tehran University of Medical Science, Pardis-e-Hemmat,Tehran (Iran, Islamic Republic of)
Description
Distribution of 10B in different regions of rat normal brain was studied. Two groups were chosen as control and trial. Trial group received 2 ml of neutral boron compound. 2, 4 and 6 h after the injection brain removed, coronal sections of forebrain, midbrain and hindbrain were sandwiched between two pieces of polycarbonate. Autoradiography plots of 10B distribution showed significant differences in three regions with the highest 10B concentration in the forebrain during 4 h after injection. - Highlights: ► Normal tissue tolerance is very important in BNCT. ► This study has been done to determine 10B distribution in three anatomical regions of rat normal brain. ► These specific regions of brain have not been studied in previous BNCT projects. ► We found significant differences in 10B distribution between these three regions. ► In different time periods after neutral boron compound injection, there has been a significant difference in boron absorption.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.apradiso.2012.03.012Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2012.03.012;
- PII
- S0969-8043(12)00213-8;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 70
- Journal Issue
- 6
- Journal Page Range
- p. 1010-1013
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 43073023
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S07: ISOTOPES AND RADIATION SOURCES;
- Descriptors DEI
- ALPHA PARTICLES; AUTORADIOGRAPHY; BORIC ACID; BORON 10; BRAIN; INJECTION; NEUTRON CAPTURE THERAPY; POLYCARBONATES; RATS
- Descriptors DEC
- ANIMALS; BODY; BORON COMPOUNDS; BORON ISOTOPES; CARBON COMPOUNDS; CARBONATES; CENTRAL NERVOUS SYSTEM; CHARGED PARTICLES; HYDROGEN COMPOUNDS; INORGANIC ACIDS; INORGANIC COMPOUNDS; INTAKE; IONIZING RADIATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEDICINE; NERVOUS SYSTEM; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; OXYGEN COMPOUNDS; POLYMERS; RADIATIONS; RADIOLOGY; RADIOTHERAPY; RODENTS; STABLE ISOTOPES; THERAPY; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.