Extreme weekly locoregional hypofractionated radiation in elderly women with non-metastatic breast cancer

Highlights: • Extreme hypofractionated radiation is a regimen delivering >5 Gy/fraction. • It is a safe alternative to normofractionation in locoregional radiation setting. • It confers excellent oncologic outcomes in term of locoregional control and survival. Breast cancer locoregional (LR) radiation in the elderly requires careful consideration between the benefits of aggressive treatment and its potential toll on these patients. Extreme weekly LR hypofractionated radiation (HFRT), delivering >5 Gy per fraction, may be better suited in such a population. It represents a good compromise between RT omission and exhaustive daily radiation. This study aims to report the local and LR control rate as well as the acute and long-term side effects of the elderly patients treated with HFRT in our institution, and to compare these results to those from the literature.