A phenomenological model for the dynamics of cell cycle in responding to X-rays

Objective: To establish a model to predict the cell-cycle process in response to ionizing radiation. Methods: Human choroidal malignant melanoma 92-1 cells were used and the cell cycle distribution of cells was analyzed in 0-96 h after exposure to X-rays. A phenomenological model was constructed based on biological knowledge to describe the cell cycle dynamics in experiments. Results: In the present study, a phenomenological model was constructed to describe the cellcycle dynamics of synchronized 92-1 cells in responding to various doses of ionizing radiation. The simulation results obtained with the model were consistent with the experimental data, demonstrating that the model had a good expansibility and could be used to predict the dynamics of cell cycle in responding to ionizing radiation. Further theoretical modeling of the cellcycle dynamics was made and the results were consistent with the simulation. Conclusions: A phenomenological model was constructed which could be used to describe the dynamics of cell cycle of cells exposed to ionizing radiation and was supported by the experimental data. Because this model is easy to run by the written code, it has a good expansibility for studying the behaviors of cell populations under various conditions. (authors)