Published December 1986
| Version v1
Report
Toxicity of inhaled 238PuO2 in Beagle dogs: A. Monodisperse 1.5 μ AMAD particles. B. Monodisperse 3.0 μm particles. XIII
Description
Beagle dogs inhaled one of two sizes of monodisperse aerosols of 238PuO2 that resulted in graded levels of 238Pu in the lung. All dogs are being studied for their life span. One-hundred and twenty-five dogs that had initial lung burdens ranging from 0.01 to 1.5 μCi 283Pu per kilogram body weight (0.37 to 56 kBq/kg) have died, eight with radiation pneumonitis and pulmonary fibrosis, 7 with lung tumors, 84 with bone tumors, 2 with liver tumors, and 24 of miscellaneous causes. Seven control dogs have died. Observations are being continued on 20 exposed and 17 control dogs alive at 3847-4675 days after exposure. 2 references, 7 figures, 1 table
Additional details
Publishing Information
- Imprint Title
- Inhalation Toxicology Research Institute: Annual report, October 1, 1985 through September 30, 1986
- Journal Page Range
- p. 215-225.
- Report number
- LMF--115
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19001439
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data, Non-conventional Literature
- Descriptors DEI
- BEAGLES; EXPERIMENTAL DATA; INHALATION; LIVER; LUNGS; NEOPLASMS; PARTICLE SIZE; PLUTONIUM 238; PNEUMONITIS; RADIATION DOSES; RADIATION EFFECTS; RESPIRATORY SYSTEM DISEASES; SKELETON; TOXICITY
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BODY; DATA; DIGESTIVE SYSTEM; DISEASES; DOGS; EVEN-EVEN NUCLEI; GLANDS; HEAVY NUCLEI; INFORMATION; INTAKE; ISOTOPES; MAMMALS; NUCLEI; NUMERICAL DATA; ORGANS; PLUTONIUM ISOTOPES; RADIOISOTOPES; RESPIRATORY SYSTEM; SIZE; SPONTANEOUS FISSION RADIOISOTO; VERTEBRATES; YEARS LIVING RADIOISOTOPES