Published December 1990
| Version v1
Journal article
Synthesis of [119mSn]-mesoporphyrin IX dichloride
Description
Tin mesoporphyrin IX dichloride (Sn-MPCl2) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [119mSn]-MPCl2 for drug metabolism and disposition studies is reported. [119mSn]-MPCl2 was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)-119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio-HPLC analysis. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 28
- Journal Issue
- 12
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 1421-1426
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 22054388
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; DIGESTIVE SYSTEM DISEASES; ENZYME INHIBITORS; LABELLING; PORPHYRINS; RADIOPHARMACEUTICALS; TIN 119
- Descriptors DEC
- CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; EVEN-ODD NUCLEI; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; STABLE ISOTOPES; SYNTHESIS; TIN ISOTOPES