Discrete subaortic stenosis (DSS): New diagnostic and pathogenic parameters gained by gated 201Tl myocardial scintigraphy (TMS) and multigated acquisition blood-pool ventriculography (MUGA)
Creators
- 1. Chaim-Sheba Medical Center, Tel-Hashomer (Israel)
- 2. Central Emek Hospital, Afula (Israel). Dept. of Nuclear Medicine
Description
Nineteen patients suffering from DSS, diagnosed by echocardiography, heart catheterization and angiography were further evaluated by radionuclide studies including ECG-gated 201TI-myocardial scintigraphy (TMS) and multigated (MUGA) acquisition blood pool ventriculography. The results of these patients were further compared with results obtained in an earlier study of 20 patients suffering from Idiopathic Hypertrophic Subaortic Stenosis (IHSS), and with a group of 28 disease-free patients all of whom were studied by the same methods. All four parameters characteristic of IHSS were demonstrated in 100% of the patients with DSS as well. The close similarity of DSS and IHSS as introduced by the results of this study, serves as an additional proof supporting our previously expressed hypothesis that most of the cases of DSS involve dynamic features similar to those obstructive cardiomyopathy. Accordingly, TMS and MUGA studies seem to provide an additional sensitive tool for the early diagnosis and evaluation of DSS patients, in a similar manner to that of IHSS patients. The value of this method for the postsurgical follow-up of DSS patients is currently investigated. (orig.)
Abstract (German)
19 Patienten mit DSS, diagnostiziert mit Echokardiographie und Laevokardiographie wurden weitergehend untersucht mit der EKG-getriggerten 201TI-Myokardszintigraphie und der multigated Blutpool-Ventrikulographie. Die Ergebnisse dieser Patienten wurden verglichen mit den Ergebnissen einer frueheren Studie an 20 Patienten mit idiopathischer hypertropher Subaorten-Stenose (IHSS) und mit einer Gruppe 28 herzgesunder Patienten, die alle mit den gleichen Verfahren untersucht worden waren. Alle 4 Parameter, die charakteristisch fuer die IHSS waren, wurden bei 100% der Patienten mit DSS ebenfalls nachgewiesen. Die sehr starke Aehnlichkeit von DSS und IHSS kann als weiterer Beweis fuer die frueher aufgestellte Hypothese, dass die meisten Faelle von DSS aehnliche haemodynamische Charakteristika wie die obstruktive Kardiomyopathie aufweisen, herangezogen werden. 201TI- und MUGA-Untersuchungen scheinen daher zusaetzliche, empfindliche Methoden darzustellen fuer die fruehe Diagnose und Abschaetzung von DSS-Patienten, aehnlich wie fuer IHSS-Patienten. Der Stellenwert dieser Methode fuer postoperative Verlaufskontrollen bei DSS-Patienten wird gegenwaertig untersucht. (orig.)Additional details
Publishing Information
- Journal Title
- Nuc Compact
- Journal Volume
- 22
- Journal Issue
- 2
- Series
- Nuc Compact.
- Journal Page Range
- 32-35
- ISSN
- 0344-3752
- CODEN
- CNNMA
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 23017032
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AORTA; CARDIOVASCULAR DISEASES; COMPARATIVE EVALUATIONS; DIAGNOSIS; DYNAMIC FUNCTION STUDIES; ELECTROCARDIOGRAMS; IMAGE PROCESSING; IMAGES; LABELLED POOL TECHNIQUES; MYOCARDIUM; PATIENTS; SCINTISCANNING; THALLIUM 201
- Descriptors DEC
- ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIAGRAMS; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVALUATION; HEART; HEAVY NUCLEI; INFORMATION; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MAN; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIOISOTOPE SCANNING; RADIOISOTOPES; THALLIUM ISOTOPES; TRACER TECHNIQUES; VERTEBRATES