Published November 1993 | Version v1
Journal article Metadata-only

Synthesis of 11-[3H]-arteether, an experimental antimalarial drug

Creators

  • 1. National Inst. of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (United States)

Description

The triphenylphosphine hydrobromide-catalyzed addition of a proton from ethanol to anhydrodihydroartemisin has been employed for the synthesis of β-arteether and 4. Use of 1.5 equivalents of EtO2H or EtO3H yielded 11-[2H]- or 11-[3H]-arteether as the major product. (Author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
33
Journal Issue
11
Journal Page Range
p. 1013-1018.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25033219
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; LABELLING; MALARIA; RADIOPHARMACEUTICALS; TRITIUM COMPOUNDS
Descriptors DEC
DISEASES; DRUGS; HEMIC DISEASES; HYDROGEN COMPOUNDS; INFECTIOUS DISEASES; LABELLED COMPOUNDS; MATERIALS; PARASITIC DISEASES; RADIOACTIVE MATERIALS; SYNTHESIS