Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents
Creators
- 1. University of Health Sciences Bozyaka Education and Training Hospital, Department of Radiology (Turkey)
- 2. Ege University School of Medicine, Department of Physiology (Turkey)
- 3. Ege University School of Medicine, Department of Anatomy (Turkey)
- 4. Ege University School of Medicine, Department of Pharmacology (Turkey)
- 5. Ege University School of Medicine, Department of Histology (Turkey)
- 6. University of Ottawa Faculty of Medicine and The Ottawa Hospital Research Institute, Department of Radiology (Canada)
Description
Purpose
This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents.Materials and methods
The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-L-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically.
Results
Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6.
Conclusion
Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
Additional details
Identifiers
Publishing Information
- Journal Title
- Japanese Journal of Radiology (Print)
- Journal Volume
- 37
- Journal Issue
- 6
- Journal Page Range
- p. 458-465
- ISSN
- 1867-1071
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 54085168
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANIMAL TISSUES; BLOOD; CYSTEINE; DEFEROXAMINE; EXCRETION; GADOLINIUM; HIPPOCAMPUS; ICP MASS SPECTROSCOPY; KIDNEYS; MINERALIZATION; RATS
- Descriptors DEC
- AMINES; AMINO ACIDS; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; BRAIN; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; CLEARANCE; ELEMENTS; MAMMALS; MASS SPECTROSCOPY; MATERIALS; METALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RARE EARTHS; RODENTS; SPECTROSCOPY; THIOLS; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2019 Japan Radiological Society