Preparation of acrylamide/maleic acid hydrogels and their biocompatibility with some biochemical parameters of human serum

In this study, the biocompatibility of acrylamide and acrylamide/maleic acid hydrogels prepared by using γ-rays has been investigated against some biochemical parameters of human serum. First, the swelling kinetics of acrylamide and acrylamide/maleic acid hydrogels were investigated in distilled water and physiological saline solution and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide and acrylamide/maleic acid hydrogels were incubated in 10 different human sera for 24 hours and their biocompatibility with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide and acrylamide/maeeic acid hydrogels are biocompatible. (Author)