Effects of chronic irradiation on age-related biochemical changes in mice
Description
Some of the biochemical indices relevant to the free radical theory of aging have been assessed in mice subjected to chronic low-dose whole-body irradiation. Radiation exposure results in enhanced accumulation of the lipofuscins in brain, heart, and intestine. In these aniamls, the degree of lipoperoxidation in liver was greatly increased, as were the free activities of acid phosphatase and cathespin, indicating damage to lysosomal membranes. The activity of SOD in brain and liver 20,000g post-mitochondrial supernatants was lower in the irradiated mice. All these changes arising from chronic whole-body irradiation are similar to those observed during aging and are effectively prevented by dietary supplementation with BHT. These observations lend considerable support to the free radical theory of aging
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 95
- Journal Issue
- 3
- Series
- Radiat. Res.
- Journal Page Range
- 637-645
- ISSN
- 0033-7587
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 15021101
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ANTIOXIDANTS; BIOCHEMISTRY; BIOLOGICAL RADIATION EFFECTS; BRAIN; CHRONIC IRRADIATION; COBALT 60; EXPERIMENTAL DATA; GAMMA RADIATION; INTESTINES; LIFE SPAN; LIPIDS; LIVER; LOW DOSE IRRADIATION; MICE; PIGMENTS; RADIOSENSITIVITY; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; CHEMISTRY; COBALT ISOTOPES; DATA; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GASTROINTESTINAL TRACT; GLANDS; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES