Published June 30, 1978 | Version v1
Miscellaneous Restricted

Studies on distribution and dosimetry of tritium water and tritium thymidine in the mother-fetus system of the rat

Creators

Description

The object of the dissertation was to compare the radiobiological efficiencies of 3H-TdR bound to DNA and HTO evenly distributed in the body liquid. The model chosen for this purpose was the model of continuous infusion in pregnant rats developed by Fliedner et al. According to earlier investigations (Haas and Fliedner, 1970), the reduction of the oocyte number in the ovaries of rat fetuses was a particularly sensitive and easily measurable parameter. (orig.)

Availability note (English)

MF available from INIS under the Report Number.

Abstract (German)

Es war das Ziel dieser Arbeit, die radiobiologische Wirksamkeit von an DNA gebundenen 3H-TdR mit dem gleichmaessig im Koerperwasser verteilten HTO zu vergleichen. Hierfuer wurde das von FLIEDNER et al. entwickelte Modell der kontinuierlichen Infusion bei schwangeren Ratten gewaehlt. Als ein besonders empfindlicher und gut messbarer Parameter fuer die radiobiologische Wirksamkeit hatte sich in frueheren Untersuchungen (HAAS und FLIEDNER, 1970) die Reduktion der Oozytenzahl in den Ovarien der Rattenfeten ergeben. (orig.)

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Additional details

Additional titles

Original title (German)
Untersuchungen zur Verteilung und Dosimetrie von Tritiumwasser und Tritiumhymidin im Mutter-Fetus-System der Ratte

Publishing Information

Imprint Pagination
89 p.
Report number
INIS-mf--5279

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
10487286
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Thesis
Descriptors DEI
DNA; INTERNAL IRRADIATION; MATHEMATICAL MODELS; PREGNANCY; RADIATION DOSE DISTRIBUTIONS; RADIOACTIVITY; RADIOBIOLOGY; RADIONUCLIDE KINETICS; RADIOSENSITIVITY; RATS; RETENTION; THYMIDINE; TRITIUM COMPOUNDS; UPTAKE
Descriptors DEC
ANIMALS; AZINES; BIOLOGY; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; IRRADIATION; KINETICS; MAMMALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RIBOSIDES; RODENTS; VERTEBRATES