Published May 1993 | Version v1
Journal article Metadata-only

Radioiodinated 2-nitrobenzyl carbamates as bioreductive alkylating agents for tissue hypoxia

Creators

  • 1. University of Western Ontario, London, ON (Canada). Dept. of Chemistry
  • 2. University of Western Ontario, London, ON (Canada). Dept. of Diagnostic Radiology and Nuclear Medicine

Description

Three N-methylcarbamates of iodonitrobenzyl alcohols (4-iodo-2-nitrobenzyl alcohol 2, 5-iodo-2-nitrobenzyl alcohol 3 and 4-iodo-2,6-dinitrobenzyl alcohol 4) bearing [125I] have been prepared and characterized for their lipophilicity, their reduction potentials and the in vivo lability of the radioiodine in healthy mice. Based upon these results, 2 and 4 were tested in tumour-bearing mice showing limited uptake of radioactivity in tumours and a tumour-to-blood ratio of less than 1. Consequently these particular carbamates are not satisfactory as hypoxia imaging agents. (Author)

Additional details

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
20
Journal Issue
4
Journal Page Range
p. 477-485.
ISSN
0883-2897
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25009901
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ALKYLATING AGENTS; ANOXIA; CARBAMATES; IODINE 125; MICE; NEOPLASMS; RADIOPHARMACEUTICALS; UPTAKE
Descriptors DEC
ANIMALS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACID SALTS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; VERTEBRATES