Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application

Highlights: • Heterocyclic amino acid derivatives templated mesoporous silicas were synthesized using biomimetic method. • Curved channels were obtained due to dynamic self-assembly of C₁₆-L-aminoacid. • Surfactant structure, pH and co-solvents influenced the final morphology and structure of mesoporous silicas. • Biomimetic synthesized mesoporous silicas possessed excellent drug loading capacity and significantly improved the drug release rate in vitro. - Abstract: The present paper reported a biomimetic synthesis of mesoporous silicas (BMSs) at room temperature by using synthesized polymers (C₁₆-l-His, C₁₆-l-Pro and C₁₆-l-Trp) which derived from amino acid with ring structures as template under basic condition via co-structural-directing-agent method. The formation mechanism of BMSs and effect of initial synthesis conditions (such as surfactant structure, pH and co-solvents) on morphology and structure of BMSs were systematically studied. Synthesized BMSs were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen adsorption/desorption isotherms. The results showed that the surfactant structure was the dominant factor to direct the final mesostructure of BMSs, since the structure of surfactant affected the structure and size of clusters. Meanwhile the generation of BMSs required very rigorous alkaline condition which controlled the ionization degree of the surfactant and thus contributing to adequate stacking energy. Higher pH resulted in construction of channels with higher curvature. The presence of ethanol was found to facilitate the formation of BMSs with larger particle size. In application, aspirin can be loaded into BMSs with high efficiency, and the drug crystalline state of aspirin transformed from crystalline state to amorphous state during this process, which undoubtedly lead to the improvement of drug dissolution from 72.8% to 100% within 90 min. It is convincible that the biomimetic method presented here provided novel insight on precisely control of mesoporous silica and undoubtedly promoted the application of mesoporous silica materials.